- Josiah Bartlett (1729-1795), the ancestor of fictional President Jed Bartlet, was a physician as well as a politician. He was the second person to sign the Declaration, following John Hancock. Following the Revolution, he was elected President and then Governor of New Hampshire.
- Matthew Thornton (1714-1803), was also a physician, like his colleague Josiah Bartlett. He arrived late to the Continental Congress, but in time to sign the document on behalf of New Hampshire. At Declaration, Thornton possibly has the most unique pizza concoction on the menu, with turkey confit, idiazabal cheese, cranberries, and maple gravy.
- William Whipple (1730-1785), was born in what would become the state of Maine and served in the Continental Congress as well as the Continental Army. General Whipple led troops against General Burgoyne at the battles of Stillwater and Saratoga. He died in 1785, having suffered from a heart ailment for several years, falling from his horse while traveling his court circuit.
- Thomas Heyward, Jr. (1746-1809), after signing the Declaration, he returned to South Carolina to serve as a judge. Imprisoned by the British during the Revolution, he returned to the bench following the war. The Heyward Pizza at Declaration contains shrimp, sweet peppers, bacon, lemon confit, spinach, and romesco.
- Thomas Lynch, Jr. (1749-1779), fell ill shortly after signing the Declaration and retired from the Congress. In 1779, he and his wife sailed for the West Indies and the ship vanished.
- Arthur Middleton (1742-1787), was captured by the British when Charleston was overrun in 1781. Imprisoned for over a year (along with Heyward and Edward Rutledge), his fortune was destroyed during the Revolution, but he remained active in politics until his death in 1787.
- Edward Rutledge (1749-1800), the youngest member of the Continental Congress, Rutledge, along with his brother John, were both very active in South Carolina politics. He left the Congress after signing the Declaration to help defend South Carolina from the British. He later returned to the state legislature and was elected Governor, but he died at the conclusion of his term, at age 50.